期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 283, 期 3, 页码 G646-G655出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00438.2001
关键词
growth hormone; thyroxine; hypophysectomy; estrogen; testosterone
资金
- NIDDK NIH HHS [R01-DK-15851] Funding Source: Medline
Hepatic alcohol dehydrogenase (ADH) activity is higher in female than in male rats. Although sex steroids, thyroid, and growth hormone (GH) have been shown to regulate hepatic ADH, the mechanism(s) for sexual dimorphic expression is unclear. We tested the possibility that the GH secretory pattern determined differential expression of ADH. Gonadectomized and hypophysectomized male and female rats were examined. Hepatic ADH activity was 2.1-fold greater in females. Because protein and mRNA content were also 1.7- and 2.4-fold greater, results indicated that activity differences were due to pretranslational mechanisms. Estradiol increased ADH selectively in males, and testosterone selectively decreased activity and mRNA levels in females. Effect of sex steroids on ADH was lost after hypophysectomy; infusion of GH in males increased ADH to basal female levels, supporting a role of the pituitary-liver axis. However, GH and L-thyroxine (T-4) replacements alone in hypophysectomized rats did not restore dimorphic differences for either ADH activity or mRNA levels. On the other hand, T-4 in combination with intermittent administration of GH reduced ADH activity and mRNA to basal male values, whereas T-4 plus GH infusion replicated female levels. These results indicate that the intermittent male pattern of GH secretion combined with T-4 is the principal determinant of low ADH activity in male liver.
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