期刊
JOURNAL OF NATURAL PRODUCTS
卷 65, 期 9, 页码 1232-1241出版社
AMER CHEMICAL SOC
DOI: 10.1021/np0200820
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资金
- NCRR NIH HHS [2G12RR03035] Funding Source: Medline
- NIGMS NIH HHS [R01-GM52277] Funding Source: Medline
The secondary metabolite composition of the gorgonian octocoral Eunicea pinta from San Andres Island, Colombia, is described for the first time. This investigation has resulted in the isolation of eight now gamma-cembranolide-type diterpenes, namely, compounds 3-10, and a new saponin, 13, possessing a pregnene-derived aglycon. In addition, two previously known alpha-methylene-gamma-lactone cembranolides, euniolide (1) and succinolide (2), were also isolated. Their structures were determined on the basis of the results of spectroscopic analysis, X-ray diffraction analysis, and chemical conversions. The discovery of cembranolides 3-10 has prompted us to conclude that the structures proposed earlier for several uprolide-type cembranolides need revision and that a minor stereochemical correction is also in order for succinolide. Cytotoxicity of compounds 3, 4, and 13 toward various cancer cell lines and results of an anti mycobacterial screening for 2, 4, and 13 also are described.
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