期刊
MOLECULAR IMMUNOLOGY
卷 38, 期 16-18, 页码 1229-1233出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0161-5890(02)00068-8
关键词
mast cells; protein tyrosine kinase Syk; signal transduction; Fe epsilon RI; histamine release
The tyrosine kinase Syk is essential for signaling from FcepsilonRI in mast cells. The Src homology domain mediated binding of Syk to the phosphorylated immunoreceptor tyrosine-based motif (ITAM) of the receptor subunits results in a conformational change and activation. Studies in Syk deficient mast cells have defined the pathways that are activated upstream and downstream of Syk and have demonstrated the functional importance of the linker region of Syk in signaling in mast cells. Published by Elsevier Science Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据