Tecadenoson -: Antiarrhythmic adenosine A1 agonist

Adenosine has been shown to be a clinically effective antiarrhythmic agent. However, because it acts on all 4 adenosine cell surface receptors (AdoRs), in addition to the cardiovascular effects beneficial for treating arrhythmias (i ' e., A, egative chronotropic, negative dromotropic, negative inotropic, anti-beta-adrenergic effects) occurring via activation of the A(1) AdoR, adenosine also exerts positive coronary vasodilatory effects via A(2A) AdoR. Thus, clinical use of the agent is associated with unwanted side effects including hypotension. Selective activation of At AdoR would eliminate induction of h tension from the possible cardioprotectant effects adenosine and/or adenosine agonists. Tecadenoson is an agent that has been shown to be highly selective for A(1) AdoR over A(2A) AdoR. It was-selected for further development in controlling heart rate during acute atrial arrhythmias, including conditions of atrial fibrillation, atrial flutter and paroxysmal supraventricular tachycardias (PSVT), without lowering blood pressure.