期刊
JOURNAL OF MASS SPECTROMETRY
卷 37, 期 9, 页码 963-973出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/jms.355
关键词
matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; metabolism; low molecular mass compounds; derivatization; bioanalysis
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) is a powerful tool for the measurement of low molecular mass compounds of biological interest. The limitations for this method are the volatility of many analytes, possible interference with matrix signals or bad ionization or desorption behavior of the compounds. We investigated the application of well-known and straightforward one-pot derivatization procedures to circumvent these problems. The derivatizations tested allow the measurement and the labeling of alcohols, aldehydes and ketones, carboxylic acids, alpha-ketocarboxylic acids and amines. Copyright (C) 2002 John Wiley Sons, Ltd.
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