期刊
HUMAN & EXPERIMENTAL TOXICOLOGY
卷 21, 期 9-10, 页码 499-505出版社
ARNOLD, HODDER HEADLINE PLC
DOI: 10.1191/0960327102ht288oa
关键词
immaturity; immune reactivity; lymphohematopoiesis; lymphopoiesis; tolerance
类别
Identifying critical windows in immune system development is crucial for determination of either safety or vulnerability to exposure to specific agents during rapidly changing phases of ontogeny. These phases in the human range from postconception early gestation through adolescence. A detailed understanding of these windows will facilitate avoidance of environmental toxins as well as allow improved planning for unavoidable exposures. Critical windows of immune development will be influenced by concomitant development, maturation and growth of other organ systems, thus the influence of potentially toxic exposures must be determined within a co-ordinated multisystem and multidisciplinary approach.
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