期刊
CLINICAL INFECTIOUS DISEASES
卷 35, 期 5, 页码 611-617出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/342201
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资金
- NIAID NIH HHS [R01 AI40350, P30-AI42853] Funding Source: Medline
- PHS HHS [R01 35543-02] Funding Source: Medline
- ODCDC CDC HHS [U64/CCU 106795] Funding Source: Medline
To evaluate correlates of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) immunoglobulin (Ig) in the genital tract, anti-HIV-gp120 IgA and IgG titers in cervicovaginal lavage specimens obtained from 104 HIV-1-infected women were measured by enzyme-linked immunosorbent assay. Overall, 24% and 94% of women had detectable anti-gp120 IgA and IgG, respectively. CD4 cell count correlated negatively with total IgA concentration (r = -0.301; P = .0027) and positively with specific IgA activity (anti-gp120 IgA titer/total IgA concentration, r = 0.306; P = .0023). Women with bacterial vaginosis had 5-fold lower anti-gp120 IgG titer ( P = .0042), 5-fold lower total IgG concentration (P less than or equal to .0001), and 4-fold higher specific IgG activity (P = .474) compared with women who did not have bacterial vaginosis. Enhanced understanding of correlates of mucosal immunity to HIV-1 may assist in the design of vaccine strategies or in the prevention of vertical transmission of HIV-1.
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