期刊
IMMUNOLOGY LETTERS
卷 83, 期 2, 页码 143-147出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-2478(02)00075-5
关键词
immunologieal synapse; ezrin; lipid rafts
类别
Although ezrin is tyrosine phosphorylated following TCR ligation, its biological role in T cell activation is not known. Here, we show that ezrin clusters at the immunological synapse upon T cell stimulation. Clustering of ezrin can be triggered by TCR ligation, or, more efficiently, by CD28 ligation. The clusters of ezrin at the immunological synapse include serine/threonine phosphorylated ezrin predominantly located within cell membrane lipid rafts. Based on these data, we propose that ezrin may play a role in the formation/stabilization of lipid raft signalosomes at the immunological synapse and therefore contribute to sustain TCR-dependent signalling. (C) 2002 Elsevier Science B.V. All rights reserved.
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