Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase

A series of bromotyrosine-derived compounds, including marine natural products and members of a psammaplin A-inspired combinatorial synthetic library, were screened for their ability to inhibit the Mycobacterium tuberculosis detoxification enzyme mycothiol-S-conjugate amidase (MCA). Correlations between the structures and their respective IC50 values (which range from 3 muM to 2.7 mM) should prove valuable when optimizing more potent inhibitors of MCA. (C) 2002 Elsevier Science Ltd. All rights reserved.