期刊
BRAIN RESEARCH
卷 948, 期 1-2, 页码 138-144出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03152-9
关键词
Alzheimer's disease; axonal transport; neurofibrillary tangle; cortical neuron; postmortem tracing
Using a novel in vitro post mortem tracing method, we demonstrate a decrease of axonal transport in the temporal cortex neurons as compared to axonal transport in the prefrontal cortex neurons in AD patients, but not in non-demented controls. The decrease of axonal transport is related to the degree of neuropathological changes, as the temporal cortex undergoes more severe neuropathological changes in AD. The present study provides, for the first time, direct evidence of the presence of impaired axonal transport in AD brains. (C) 2002 Elsevier Science B.V. All rights reserved.
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