Increased aquaporin I water channel expression in human brain tumours

Aquaporin I is a water channel protein. There was little aquaporin I immunoreactivity in normal brain parenchyma. In astrocytomas, aquaporin I was expressed in microvessel endothelia and neoplastic astrocytes. In metastatic carcinomas, aquaporin I was present in microvessel endothelia and reactive astrocytes. Aquaporin I may participate in the formation of brain tumour oedema. (C) 2002 Cancer Research UK.