期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 87, 期 3-4, 页码 379-384出版社
ELSEVIER
DOI: 10.1016/S0165-2427(02)00076-4
关键词
canine; atopic dermatitis; cytokines; T-helper 1; T-helper 2; interleukin 4; transforming growth factor beta
Atopic dermatitis is a common inflammatory skin disease of humans and dogs. Human atopic dermatitis is associated with T-helper (Th) 2 type responses. although Th1 cytokines are present in chronic lesions. This study used semi-quantitative reverse transcriptase polymerase chain reactions to determine the expression of gene transcripts for immunosuppressive cytokines (transforming growth factor beta [TGFbeta] and interleukin [IL]-10), Th2 type cytokines (IL-4 and IL-6) and Th1 type cytokines (interferon gamma [IFNgamma], tumour necrosis factor alpha [TNFalpha], IL-2 and IL-12) in lesional atopic, non-lesional atopic and healthy canine skin. Canine atopic dermatitis was associated with overexpression of IL-4 mRNA and reduced transcription of TGFbeta compared to healthy skin (ANOVA, p < 0.05). Higher levels of IFNgamma, TNFalpha and IL-2 mRNA were seen in lesional compared to non-lesional and healthy skin (p < 0.05). There were no significant differences in IL-10, IL-6 or IL-12 transcription. This is the first report to demonstrate that canine atopic dermatitis is associated with over-production of IL-4 and under expression of TGFbeta. (C) 2002 Elsevier Science B.V. All rights reserved.
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