期刊
DESALINATION
卷 146, 期 1-3, 页码 75-81出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0011-9164(02)00492-7
关键词
filter sizing; scale up; microfiltration; fouling; normal flow filtration
Proper sizing and scale-up of normal flow filtration devices requires an understanding of the effects of membrane fouling on system capacity. The V-max test is often used to accelerate testing and reduce the required process volume, but the underlying assumption that fouling occurs by uniform constriction of cylindrical membrane pores is rarely met in practice. We have examined the validity of the V-max model and have compared the results with predictions of a new model that accounts for fouling due to both pore blockage and cake formation. The V-max analysis significantly overestimates the system capacity for proteins like bovine serum albumin that foul primarily by pore blockage, but it underestimates the capacity for lysozyme which fouls primarily by cake formation. In contrast, the pore blockage-cake filtration model provides a much better description of membrane fouling, leading to more accurate sizing and scale-up of normal flow filtration devices.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据