期刊
FEBS LETTERS
卷 527, 期 1-3, 页码 91-94出版社
WILEY
DOI: 10.1016/S0014-5793(02)03171-X
关键词
methionine sulfoxide; reactive oxygen species; oxidative stress; posttranslational modification; potassium channel
资金
- NIGMS NIH HHS [GM 57654] Funding Source: Medline
Human CBS1 is a methionine sulfoxide reductase of type B (MSRB) as it specifically reduced Met-R-SO in peptides with dithiothreitol or the thioredoxin system as reductants. Mutation C169S in the active site completely abolished enzymatic activity, while mutation W110A only reduced activity and C105S had no effect. Like human MSRA, hCBS1 showed in vivo reducing activity coexpressed with the Drosophila ShC/B potassium channel in oocytes, by accelerating the overall inactivation time course. hCBS1-encoding mRNA is most abundant in muscle tissues, especially in the heart and thereby shows an expression pattern different to the human MSRA. (C) 2002 Federation of European Biochemical Societies.
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