期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
卷 1577, 期 2, 页码 276-286出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4781(02)00458-X
关键词
transcription elongation; chromatin; RNA polymerase II; nucleosome; FACT; DSIF
Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and historic modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin. (C) 2002 Elsevier Science B.V All rights reserved.
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