期刊
BRAIN RESEARCH
卷 949, 期 1-2, 页码 209-212出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)03157-8
关键词
sleep; GABA; GAD; cytokines
资金
- NIMH NIH HHS [MH60308] Funding Source: Medline
- NINDS NIH HHS [NS27250, NS25378] Funding Source: Medline
GHRH and IL1beta regulate steep via the hypothalamus. However, actions of these substances on neurons are poorly understood. In this study, we found both GHRH (100 nM) and IL1beta (1.2 pM) acutely increased cytosolic Ca2+ in 7.6 and 4.0% of cultured hypothalamic neurons tested, respectively, and 1.2% of neurons responded to both. The neurons that responded were mostly GABAergic (96, 81, and 100%, for GHRH, IL1beta, and dual-responsive neurons, respectively). (C) 2002 Elsevier Science B.V. All rights reserved.
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