期刊
JOURNAL OF INFECTIOUS DISEASES
卷 186, 期 6, 页码 737-742出版社
UNIV CHICAGO PRESS
DOI: 10.1086/342972
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资金
- NCI NIH HHS [CA-13330] Funding Source: Medline
- NIAID NIH HHS [AI-31055] Funding Source: Medline
A high incidence of initial infection with human papillomavirus (HPV) was previously reported in a cohort of 608 women monitored at 6-month intervals for 3 years. Risk factors for subsequent infections with different HPV types and whether antibodies against HPV-16 virus-like particles (VLPs) protected against these infections were examined. Subsequent infections with HPV are very common. Seventy percent of women acquired a different HPV type within 24 months of the initial infection. Risk factors included being nonwhite, having an increased number of male sex partners, and having had a new male sex partner. Use of oral contraceptive pills was protective. A sustained high level of IgG antibody to HPV-16 VLPs was associated with reduced risk for subsequent infection with HPV-16 and its genetically related types (i.e., HPV-31, -33, -35, -52, and -58).
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