期刊
ORGANIC LETTERS
卷 4, 期 19, 页码 3231-3234出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol026438g
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资金
- NIGMS NIH HHS [GM-45617] Funding Source: Medline
A highly convergent total synthesis of (+)-brefeldin A that relies on a diastereoselective, beta-lactone-based cyclopentane synthesis combined with complex cross-metathesis reactions is described. The utility of beta-lactones for natural product synthesis and the versatility of cross-metathesis in this context were demonstrated, including the tolerance of an epimerizable aldehyde and a beta-lactone.
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