期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1565, 期 1, 页码 36-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0005-2736(02)00503-5
关键词
Saccharomyces cerevisiae; ion homeostasis; protein kinase; salt tolerance; potassium transport; membrane potential
Protein kinases dedicated to the phosphorylation of SR proteins have been implicated in the processing and nuclear export of mRNAs. Here we demonstrate in Saccharomyces cerevisiae their participation in cation homeostasis. A null mutant of the single yeast SR protein kinase Sky1p is viable but exhibits increased tolerance to diverse toxic cations such as Na+, Li+, spermine, tetramethylammonium, hygromycin B and Mn2+. This pleiotropic phenotype correlates with reduced accumulation of cations, suggesting a decrease in membrane electrical potential. Genetic analysis and Rb+ uptake measurements indicate that Sky1p modulates Trk 1,2, the high-affinity K+ uptake system of yeast and a major determinant of membrane potential. (C) 2002 Elsevier Science B.V. All rights reserved.
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