期刊
TETRAHEDRON
卷 58, 期 39, 页码 7903-7910出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(02)00915-8
关键词
copper; catalysis; diaryl ether; verbenachalcone; nerve growth factor
2-Hydroxy-2'-methoxydiphenyl ethers were efficiently assembled utilizing a catalytic copper mediated coupling of 2-benzyl-oxybromobenzene derivatives and 2-methoxyphenol derivatives in the presence of cesium carbonate in pyridine followed by debenzylation. Utilization of this method allowed for a concise synthesis of verbenachalcone, a compound reported to enhance nerve growth factor's ability to stimulate neurite outgrowths in PC12D cells. Initial SAR data is also presented. (C) 2002 Elsevier Science Ltd. All rights reserved.
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