期刊
NEUROLOGY
卷 59, 期 6, 页码 944-946出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.59.6.944
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资金
- NINDS NIH HHS [P01 NS32352-P2] Funding Source: Medline
The authors immunocytochemically identified mesopontine cholinergic and rostral raphe serotonergic neurons in brains obtained at autopsy from four patients with multiple system atrophy (MSA) and four matched controls. There was a severe depletion of cholinergic neurons in the pedunculopontine (20 +/- 2 vs 81 +/- 10 cells/section, p < 0.001) and laterodorsal tegmental nucleus (18 +/- 3 vs 47 +/- 4 cells/section, p < 0.001) in MSA. Whereas there was also depletion of locus ceruleus neurons, there was a striking preservation of rostral raphe neurons in MSA.
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