期刊
FEBS LETTERS
卷 528, 期 1-3, 页码 246-250出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03238-6
关键词
separase; securin; chromatid separation; anaphase; cysteine protease
资金
- NIGMS NIH HHS [GM26875-17, GM39023-08] Funding Source: Medline
Sister-chromatid separation is triggered by a specific proteolytic cleavage of chromosomal cohesins catalyzed by the endopeptidase separase. Prior to anaphase, separase is inhibited independently by affinity binding to securin and by specific inhibitory phosphorylation. Here we show that separase itself is also subjected to proteolytic cleavages at three adjacent sites. The cleavages are auto-catalyzed and occur specifically at anaphase coincident with separase activation. The cleaved fragments remain associated with each other and are catalytically active. Mapping of the cleavage sites reveals that all three sites are conserved in vertebrates underlining a significant function for this regulation. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
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