期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 50, 期 20, 页码 5533-5538出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf025581l
关键词
evening primrose oil; Oenothera biennis; Onagraceae; caffeoyl ester; triterpenoid acids; radical scavenger; DPPH radical; neutrophil elastase; cyclooxygenase; in vitro
Cold-pressed, non raffinated evening primrose oil was found to contain lipophilic radical scavengers. A highly enriched fraction of these compounds could be obtained from the oil by extraction with aqueous ethanol and subsequent liquid-liquid partitioning with petroleum. LC DAD MS analysis revealed that the fraction contained three aromatic compounds with identical UV and ESI-MS spectra. The compounds were isolated by RP-HPLC and their structures established by chemical and spectroscopic means as 3-O-trans-caffeoyl derivatives of betulinic, morolic, and oleanolic acid. The morolic acid derivative was a new compound. The three esters exhibited pronounced radical scavenging activity against the stable 2,2 diphenyl 1 picrylhydrazyl radical and were potent inhibitors of neutrophil elastase and cyclooxygenase 1 and -2 in vitro. Commercial samples of evening primrose oils contained only traces of these lipophilic antioxidants.
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