期刊
SCIENCE
卷 297, 期 5590, 页码 2256-2259出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1074807
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资金
- NCI NIH HHS [CA-86065] Funding Source: Medline
- NIAID NIH HHS [5T32AI07290-16] Funding Source: Medline
To rigorously test the in vivo cell fate specificity of bone marrow ( BM) hematopoietic stem cells (HSCs), we generated chimeric animals by transplantation of a single green fluorescent protein (GFP)-marked HSC into lethally irradiated nontransgenic recipients. Single HSCs robustly reconstituted peripheral blood leukocytes in these animals, but did not contribute appreciably to nonhematopoietic tissues, including brain, kidney, gut, liver, and muscle. Similarly, in GFP(+):GFP(-) parabiotic mice, we found substantial chimerism of hematopoietic but not nonhematopoietic cells. These data indicate that transdifferentiation of circulating HSCs and/or their progeny is an extremely rare event, if it occurs at all.
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