期刊
JOURNAL OF CELL BIOLOGY
卷 158, 期 7, 页码 1183-1193出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200205028
关键词
centriole duplication; basal body; tubulin; cytoskeleton; paramecium
类别
Centrioles and basal bodies fascinate by their spectacular architecture, featuring an arrangement of nine microtubule triplets into an axial symmetry, whose biogenesis relies on yet elusive mechanisms. However, the recent discovery of new tubulins, such as delta-, epsilon, or, eta-tubulin, could constitute a breakthrough for deciphering the assembly steps of this unconventional microtubule scaffold. Here, we report the functional analysis in vivo of epsilon-tubulin, based on gene silencing in Paramecium, which demonstrates that this protein, which localizes at the basal bodies, is essential for the assembly and anchorage of the centriolar microtubules.
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