期刊
DIABETOLOGIA
卷 45, 期 10, 页码 1468-1474出版社
SPRINGER
DOI: 10.1007/s00125-002-0937-z
关键词
Type I diabetes; autoimmune disease; vaccination; HSP60; peptide p277; immune modulation; hypothesis driven research; immunological homunculus
The autoimmune process that produces Type I (insulin-dependent) diabetes mellitus seems to respond favourably to therapeutic vaccination with a peptide of the 60 kDa heat shock protein. This article is a personal review of the observations and the thinking that gave rise to the idea of therapeutic peptide vaccination. The rationale for vaccination therapy is compared to other approaches aimed at specific immunological treatment for autoimmune disease.
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