期刊
CURRENT OPINION IN CELL BIOLOGY
卷 14, 期 5, 页码 633-639出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(02)00364-2
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Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.
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