期刊
NATURE REVIEWS IMMUNOLOGY
卷 2, 期 10, 页码 748-759出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri912
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Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs) - a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species - in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.
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