期刊
GLIA
卷 40, 期 1, 页码 65-77出版社
WILEY-LISS
DOI: 10.1002/glia.10116
关键词
stem cells; human; differentiation; precursor cell; central nervous system; glia; embryonic; A2B5; astrocyte; oligodendrocyte; in vitro
资金
- NICHD NIH HHS [HD39702] Funding Source: Medline
- NINDS NIH HHS [NS37166] Funding Source: Medline
The identification and characterization of human neural precursor cells are critical in extending our understanding of central nervous system development from model animal systems to our own species. Moreover, availability of well-characterized populations of human cells is of potential value in endeavors ranging from cell transplantation to drug screening. We have isolated a population of continuously dividing glial-restricted precursor cells from commercially available cryopreserved 18-20 weeks old fetal brain neural progenitor cells. These human glial-restricted precursor cells are A2B5(+) and do not express polysialylated E-NCAM (PSA-NCAM). They can be grown as purified populations in serum-free medium supplemented with basic fibroblast growth factor (bFGF) and can be induced to generate cells with the antigenic characteristics of oligodendrocytes and distinct astrocytic populations. (C) 2002 Wiley-Liss, Inc.
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