期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 17, 期 10, 页码 1825-1828出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/17.10.1825
关键词
dialysis patients; feasibility; hepatitis A; immunization; immunogenicity; reactogenicity
Background. This study investigated the feasibility, immunogenicity, and reactogenicity of hepatitis A vaccination in end-stage renal failure patients who were on chronic intermittent haemodialysis. Methods. Forty-three subjects were vaccinated with an inactivated hepatitis A vaccine according to a 0-, 1-, and 6-month immunization schedule. Two groups were established who received the vaccine either intramuscularly (group A, n = 30) or subcutaneously (group B, n = 13). Results. All patients in group A and 12/13 in group B developed antibodies against hepatitis A. The geometric mean titres (GMT) were high and similar to those observed in healthy subjects. There was a tendency to higher GMT in the group who received the vaccine subcutaneously. No clinically significant adverse events were observed, and the liver enzyme profile showed no abnormalities. Conclusions. We showed that hepatitis A vaccination of dialysis patients is feasible, well tolerated and immunogenic and that the vaccine can be given subcutaneously in those patients where intramuscular administration is contra-indicated.
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