期刊
MICROSCOPY RESEARCH AND TECHNIQUE
卷 59, 期 1, 页码 41-48出版社
WILEY-LISS
DOI: 10.1002/jemt.10175
关键词
hypoxia; HIF-1; HIF-2; angiogenesis; glycolysis; carbonic anhydrases
Hypoxia, a common consequence of solid tumor growth in breast cancer and other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and alterations in microenvironmental pH. Hypoxia-inducible factors, heterodimeric DNA binding complexes composed of two subunits, provide critical regulation of this response. This review presents a synopsis of the genes induced by hypoxia in the context of breast cancer and discusses how upregulation of HIF-1 activity, and the homologous factor HIF-2, are not only fundamental for the adaptation to hypoxia but also may be critical for tumor progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据