期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 131, 期 1-2, 页码 173-178出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00255-2
关键词
Lyme neuroborreliosis; cerebrospinal fluid; IL-12; IL-18; sCD30
Lyme neuroborreliosis is a complex disease with different clinical outcomes and where immunopathological mechanisms are probably involved. In this study, sera and cerebrospinal fluid (CSF) from 21 neuroborreliosis patients and 26 control patients were analyzed for the Th1-inducing cytokines, interleukin (IL)-12 and IL-18, and the Th2 associated, soluble CD30 (sCD30) by ELISA. The results showed an increased number of neuroborreliosis patients expressing IL-12 (p<0.05) and IL-18 (p<0.05) in the CSF when compared with the controls, but no indication of increased levels in the sera. Nor were there any differences regarding levels of sCD30 in the sera or the CSF, indicating a local Th1-generating milieu in the target organ of neuroborreliosis. (C) 2002 Elsevier Science B.V. All rights reserved.
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