期刊
PHARMACEUTICAL RESEARCH
卷 19, 期 10, 页码 1389-1399出版社
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1020427227285
关键词
camptothecin; antitumor activity; solubility; insolubility
Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers. Camptothecin, however, like a number of other potent anticancer agents such as paclitaxel, is extremely water insoluble. Furthermore, pharmacology studies have determined that prolonged schedules of administration given continuously are required. Thus, this insolubility has restricted its clinical application. For these reasons, a number of water-soluble analogs have been synthesized and a number of different formulation approaches have been investigated. In this review, we examine each of these approaches and discuss their advantages and limitations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据