期刊
HUMAN IMMUNOLOGY
卷 63, 期 10, 页码 912-925出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0198-8859(02)00449-4
关键词
allorecognition; T cells; graft rejections; direct/indirect pathways
类别
资金
- NEI NIH HHS [1R01 EY 013310-01A1] Funding Source: Medline
In this study, we measured direct and indirect T-cell alloresponses mediated by CD4(+) and CD8(+) T cells in three mouse transplantation models: skin, cornea, and retina. We show that the contribution of direct and indirect antigen recognition pathways to the alloresponse to fully allogeneic grafts varies depending upon the nature of the tissue/organ transplanted. The implications of this finding for understanding the cellular mechanisms by which rejection is mediated in different transplant models are discussed. (C) American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.
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