期刊
BRAIN RESEARCH REVIEWS
卷 40, 期 1-3, 页码 45-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0173(02)00187-X
关键词
serotonin; 5-hydroxytryptamine (5-HT); raphe; spinal cord; cat; motor activity; fatigue; pain; sympathetic activity
资金
- NIMH NIH HHS [MH-23433] Funding Source: Medline
In the mammalian brain, serotonergic neurons in the medulla (n. raphe magnus, obscurus, and pallidus) send dense projections into the spinal cord, especially to the dorsal horn, intermediolateral column, and ventral horn. We have conducted a series of studies examining the single unit activity of these neurons in behaving cats. The experiments were directed at determining whether changes in unit activity were related to pain (n. raphe magnus), autonomic activity (n. raphe obscures and pallidus), or motor activity (n. raphe obscurus and pallidus). The strongest relationship was between neuronal activity and motor output, especially tonic and repetitive motor activity. We hypothesize that the primary functions of this motor-related activity are to facilitate motor output, suppress processing of some forms of afferent activity, and to coordinate autonomic functioning with the current motor demand. (C) 2002 Published by Elsevier Science B.V.
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