期刊
INFECTION GENETICS AND EVOLUTION
卷 2, 期 1, 页码 39-45出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-1348(02)00089-8
关键词
Age; Salmonella; Multilocus sequence typing; Housekeeping gene; Sequence diversity; Clone; Epidemic disease; Microbial evolution
资金
- Deutsche Forschungsgemeinschaft [Ac 36/9-2]
- Wellcome Trust, Great Britain
A global collection of 26 isolates of Salmonella typhi was investigated by sequencing a total of 3336 bp in seven housekeeping genes. Only three polymorphic sites were found and the isolates fell into four sequence types. These results show that S. typhi is a recent clone whose last common ancestor existed so recently that multiple mutations have not yet accumulated. Based on molecular clock rates for the accumulation of synonymous polymorphisms, we estimate that the last common ancestor of S. typhi existed 15,000-150,000 years ago, during the human hunter-gatherer phase and prior to the development of agriculture and the domestication of animals. (C) 2002 Elsevier Science B.V. All rights reserved.
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