期刊
ANIMAL GENETICS
卷 33, 期 5, 页码 329-337出版社
WILEY
DOI: 10.1046/j.1365-2052.2002.00885.x
关键词
coat colour; gene mapping; grey; horse genetics; microsatellite
The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (G(G)). In this study, two paternal Quarter Horse (QH) families segregating for the G(G) allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF=0.02, LOD=12.04) on horse chromosome 25 (ECA25). Further chromosome-specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43-(0.24)- UCDEQ405-(0.09) -COR080-(0.05)- GREY -(0.14)- UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome-specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel17) genes as possible candidates for the grey phenotype in horses.
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