期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 131, 期 1-2, 页码 135-146出版社
ELSEVIER
DOI: 10.1016/S0165-5728(02)00272-2
关键词
Alzheimer's; factor H; heparan sulfate proteoglycan; agrin; complement receptor 3; amyloid beta
资金
- NIA NIH HHS [AGO7367] Funding Source: Medline
- NINDS NIH HHS [NS33981] Funding Source: Medline
Factor H, a regulatory protein of the alternative pathway of complement (APC), is present in amyloid-beta (Abeta) plaques in Alzheimer's disease (AD). Abeta plaques also contain significant amounts of heparan sulfate proteoglycans (HSPGs), such as agrin, as well as numerous activated microglia expressing increased levels complement receptor 3 (CR3). Here, we show the colocalization of each of these molecules in the AD brain and the functional capacity for these molecules to bind to one another in vitro. We propose that CR3 receptors expressed by microglia are used for ligand binding to factor H bound to HSPGs and Abeta in plaques in the AD brain. (C) 2002 Elsevier Science B.V. All rights reserved.
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