期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 93, 期 4, 页码 1487-1497出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00053.2002
关键词
adaptation; contractile function; fatigue; myosin heavy chain; paralysis; plasticity
资金
- NINDS NIH HHS [NS-16333] Funding Source: Medline
The effects of a complete spinal cord transection (ST) on the mechanical properties of the rat soleus were assessed 3 and 6 mo post-ST and compared with age-matched controls. Maximal tetanic force was reduced by similar to44 and similar to25% at 3 and 6 mo post-ST, respectively. Similarly, maximum twitch force was reduced by similar to29% in 3-mo and similar to17% in 6-mo ST rats. ST resulted in faster twitch properties as evidenced by shorter time to peak tension (similar to45%) and half-relaxation time (similar to55%) at both time points. Maximum shortening velocity was significantly increased in ST rats whether measured by extrapolation from the force-velocity curve (approximately twofold at both time points) or by slack-test measurements (over twofold at both time points). A significant reduction in fatigue resistance of the soleus was observed at 3 (similar to25%) and 6 mo (similar to45%) post-ST. For the majority of the speed-related properties, no significant differences were detected between 3- and 6-mo ST rats. However, the fatigue resistance of the soleus was significantly lower in 6- vs. 3- mo ST rats. These data suggest that, between 3 and 6 mo post-ST, force-related properties tended to recover, speed-related properties plateaued, and fatigue-related properties continued to decline. Thus some specific functional properties of the rat soleus related to contractile force, speed, and fatigue adapted independently after ST.
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