期刊
SPINAL CORD
卷 40, 期 10, 页码 524-528出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.sc.3101320
关键词
creatinine; cystatin C; cysteine proteinase inhibitors; glomerular filtration rate; kidney function; spinal cord injury
Objective: To investigate the relationship between serum cystatin C, serum creatinine, and Cr-51-EDTA-clearance in patients with spinal cord injury. Setting: The Spinal Cord Unit, Viborg-Kjellerup County Hospital. Methods: Twenty-four men and seven women aged 20.3 to 68.0 years with motor complete spinal cord injury (ASIA A or B) were included. Serum cystatin C was measured by an automated particle-enhanced nephelometric immunoassay (Dade Behring), serum creatinine by an enzymatic method (Vitros 950), and Cr-51-EDTA-clearance by a multiple plasma sample method. Results: A linear relationship was found between Cr-51-EDTA-clearance and the reciprocal values of cystatin C and creatinine. The correlation coefficient between Cr-51-EDTA-clearance and 1/cystatin C was 0.72 compared to the correlation coefficient between Cr-51-EDTA-clearance and 1/creatinine being 0.26. Comparison of the area under the curves in the non-parametric receiver operating characteristics (ROC) plots for serum cystatin C (area under the curve (AUC)=0.912; SE=0.065), and serum creatinine (AUC=0.507; SE=0.115) revealed significant differences (P-values=0.0005). Conclusion: In patients with spinal cord injury serum cystatin C is a better marker of the renal function compared to serum creatinine.
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