期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 19, 期 10, 页码 1760-1768出版社
OXFORD UNIV PRESS
DOI: 10.1093/oxfordjournals.molbev.a003998
关键词
protein interaction networks; microarrays; gene knockout; biochemical innovation
资金
- NIGMS NIH HHS [GM63882] Funding Source: Medline
Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Here, I present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations.
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