期刊
JOURNAL OF PEDIATRICS
卷 141, 期 4, 页码 512-517出版社
MOSBY-ELSEVIER
DOI: 10.1067/mpd.2002.127665
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Objectives: To determine risk factors for acquiring Burkbolderia cepacia complex among patients with cystic fibrosis (CF). Study design: A case-control study v was conducted with active surveillance for B cepacia complex colonization/infection among patients at 21 CF centers from April 1986 to March 1989 (study, period). A case-patient was defined as any CF patient with B cepacia complex colonization for the first time during the study period. Control patients were patients with CF not B cepacia complex colonized during the study period. For each patient, a questionnaire was completed semiannually. Results: In multivariate analyses, hospitalization for pulmonary exacerbations, living with a B cepacia complex-positive person, attending a CF summer camp, and direct contact with a B cepacia complex-colonized CF person outside of camp and home were associated with B cepacia complex acquisition. Receiving antimicrobial aerosol therapy or cleaning and drying a home-used nebulizer between uses, were associated with a decrease in B cepacia complex acquisition, Conclusions: Numerous factors inside and outside the health care setting are associated with person-to-person transmission of B cepacia complex among patients with CF. Prevention programs should reduce direct or indirect contact between noncolonized and B cepacia z complex-colonized/infected patients with CF.
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