期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 46, 期 10, 页码 3288-3291出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.46.10.3288-3291.2002
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We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus. Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.
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