期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 99, 期 20, 页码 13194-13199出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.202471399
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资金
- NCRR NIH HHS [P41RR08079, P41 RR008079] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000329, EB00329] Funding Source: Medline
- NINDS NIH HHS [NS39043, R01 NS041262, R01 NS039043, NS41262, NS38070] Funding Source: Medline
A comprehensive technique was developed for using three-dimensional O-17 magnetic resonance spectroscopic imaging at 9.4T for rapidly imaging the cerebral metabolic rate of oxygen consumption (CMRO2) in the rat brain during a two-min inhalation of O-17(2). The CMRO2 value (2.19 +/- 0.14 mumol/g/min, n = 7) was determined in the rat anesthetized with alpha-chloralose by independent and concurrent O-17 NMR measurements of cerebral (H2O)-O-17 content, arterial input function, and cerebral perfusion. CMRO2 values obtained were consistent with the literature results for similar conditions. Our results reveal that, because of its superior sensitivity at ultra-high fields, the O-17 magnetic resonance spectroscopic imaging approach is capable of detecting small dynamic changes of metabolic (H2O)-O-17 during a short inhalation of O-17(2) gas, and ultimately, for imaging CMRO2 in the small rat brain. This study provides a crucial step toward the goal of developing a robust and noninvasive O-17 NMR approach for imaging CMRO2 in animal and human brains that can be used for studying the central role of oxidative metabolism in brain function under normal and diseased conditions, as well as for understanding the mechanisms underlying functional MRI.
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