期刊
SEMINARS IN IMMUNOLOGY
卷 14, 期 5, 页码 343-349出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/S1044-5323(02)00067-2
关键词
preBCR; proBCR; Ig gene rearrangement; surrogate light chain
类别
资金
- NIAID NIH HHS [AI39816, T32 AI007051, AI48098] Funding Source: Medline
Only a subpopulation of relatively large pre-B cells express pre-B cell receptors (preBCR) that can be seen with very sensitive immunofluorescence methods. Inefficient assembly of the multicomponent preBCR coupled with their ligand-induced endocytosis may account for the remarkably low in vivo Levels of preBCR expression. Signaling initiated via the preBCR promotes cellular proliferation and RAG-1 and RAG-2 downregulation to interrupt the immunoglobulin V(D)J gene rearrangement process. Silencing of the surrogate light chain genes, VpreB and; 5, then terminates preBCR expression to permit cell cycle exit, recombinase gene upregulation, and VJ(L) rearrangement by small pre-B cells destined to become B cells.
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