期刊
FEBS LETTERS
卷 529, 期 1, 页码 122-125出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(02)03270-2
关键词
e217; apoptosis; p14ARF; p53; p73; ApafI
The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation and their activity is often deregulated in human tumors. Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1-induced apoptosis occurs via multiple pathways, some of which induce stabilization and activation of the tumor suppressor p53. The pro-apoptotic activity of E2F1 suggests that its deregulation constitutes an oncogenic stress that may target pre-malignant cells to undergo apoptosis, thus preventing tumor development. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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