Diazonamide synthesis studies: Use of Negishi coupling to fashion diazonamide-related biaryls with defined axial chirality

[GRAPHICS] The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropselectivity in these biaryl systems is enforced by an sp(3) stereogenic center in a lactone tether in both cases.