期刊
SCIENCE
卷 298, 期 5591, 页码 216-218出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1075642
关键词
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资金
- NIGMS NIH HHS [GM61351] Funding Source: Medline
The detection of single-nucleotide polymorphisms in pathogenic microorganisms has normally been carried out by trial and error. Here we show that DNA hybridization with high-density oligonucleotide arrays provides rapid and convenient detection of single-nucleotide polymorphisms in Plasmodium falciparum, despite its exceptionally high adenine-thymine (AT) content (82%). A disproportionate number of polymorphisms are found in genes encoding proteins associated with the cell membrane. These genes are targets for only 22% of the oligonucleotide probes but account for 69% of the polymorphisms. Genetic variation is also enriched in subtelomeric regions, which account for 22% of the chromosome but 76% of the polymorphisms.
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