期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 67, 期 20, 页码 7162-7164出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0257400
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A short, efficient, and diastereomerically pure synthesis of N-Boc-cis-4-trifluoromethyl-L-proline (7) and N-Boc-cis-4-difluoromethyl-L-proline (9) from N-Boc-4-oxo-L-proline (4) is described. The reaction of 4 with Me3SiCF3 and the conversion of the carbonyl group of 4 into the difluoromethylene group are the key steps for the synthesis of 7 and 9, respectively.
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