期刊
VACCINE
卷 20, 期 29-30, 页码 3598-3612出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(02)00309-2
关键词
therapeutic vaccine; induction of T-cell response; treatment in chronic HBV infection
We characterized the anti-viral T-cell response in 22 chronically infected patients, who participated in a European multi-center randomized placebo-controlled, double-blind study therapeutic vaccination trial with pre-S1, pre-S2 and S antigenic components of the hepatitis B virus (HBV). It induced a significant HBsAg-specific T-cell proliferation and the production of Th2-cytokines (i.e. IL-5). A specific induction of Th1-lymphokines was not detectable although this has been demonstrated in this study in response to the nucleocapsid protein (HBcAg). Further analysis indicated that this approach does not activate HBV-specific CD8+ T-lymphocytes as detected by ELISPOT-assay. Our results might explain why a specific therapeutic vaccine, although safe and well-tolerated is not always able to break tolerance leading to the clearance of the hepatitis B virus. (C) 2002 Elsevier Science Ltd. All rights reserved.
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